Chemicals and Drugs

Histidine Kinase

A member of the transferase superfamily of proteins. In the activated state, protein-histidine kinase autophosphorylates at a histidine residue, subsequently transferring high-energy phosphoryl groups to an aspartate residue of the response-regulator domain, which results in a conformational shift in the effector domain. Histidine kinases mediate signal transduction in a wide range of processes involving cellular adaptation to environmental stress.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A member of the transferase superfamily of proteins. In the activated state, protein-histidine kinase autophosphorylates at a histidine residue, subsequently transferring high-energy phosphoryl groups to an aspartate residue of the response-regulator domain, which results in a conformational shift in the effector domain. Histidine kinases mediate signal transduction in a wide range of processes involving cellular adaptation to environmental stress.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

21 entry terms
  • Histidine Protein Kinase
  • Protein-Histidine Kinase
  • Kinase, Histidine
  • Kinase, Histidine Protein
  • Kinase, Protein-Histidine
  • Protein Histidine Kinase
  • Protein Kinase, Histidine
  • Histone H4 Histidine Kinase
  • Protein Histidine Pros-Kinase
  • Protein Kinase (Histidine), Pros-Kinase
  • Protein-Histidine Pros-Kinase
  • Protein-Histidine Tele-Kinase
  • Sensor Histidine Kinase
  • Histidine Kinase, Sensor
  • Histidine Pros-Kinase, Protein
  • Kinase, Sensor Histidine
  • Pros-Kinase, Protein Histidine
  • Pros-Kinase, Protein-Histidine
  • Protein Histidine Pros Kinase
  • Protein Histidine Tele Kinase
  • Tele-Kinase, Protein-Histidine

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (1986)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.620.682w.424w

AMA Style

References

  1. National Library of Medicine. Histidine Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D000071677. http://id.nlm.nih.gov/mesh/2026/D000071677
  2. Histidine Kinase. In: Wikipedia. https://en.wikipedia.org/wiki/Histidine_kinase
  3. Histidine Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q1620721