Diseases

Hirschsprung Disease

Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

17 entry terms
  • Aganglionic Megacolon
  • Congenital Megacolon
  • Hirschsprung's Disease
  • Megacolon, Aganglionic
  • Megacolon, Congenital
  • Disease, Hirschsprung
  • Disease, Hirschsprung's
  • Hirschsprungs Disease
  • Aganglionosis, Colonic
  • Aganglionosis, Rectosigmoid Colon
  • Aganglionosis, Total Colonic
  • Colonic Aganglionosis
  • Congenital Intestinal Aganglionosis
  • Rectosigmoid Aganglionosis
  • Total Colonic Aganglionosis
  • Aganglionosis, Rectosigmoid
  • Rectosigmoid Colon Aganglionosis

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

acquired megacolon = MEGACOLON

MeSH Record

History Note

83; was HIRSCHSPRUNG'S DISEASE see MEGACOLON 1963-82

MeSH Record

Previous Indexing

  • Megacolon (1966-1982)

MeSH Hierarchy

Tree Numbers

  1. C06w.198.439w
  2. C06w.405w.469w.158.701w.439w
  3. C16w.131w.314.439w

MeSH Record

NLM Classification

WI 528

AMA Style

References

  1. National Library of Medicine. Hirschsprung Disease. Medical Subject Headings (MeSH). 2026. Unique ID D006627. http://id.nlm.nih.gov/mesh/2026/D006627
  2. Hirschsprung Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Hirschsprung%27s_disease
  3. Hirschsprung Disease. In: Wikidata. https://www.wikidata.org/wiki/Q1343645