Chemicals and Drugs

Heterogeneous-Nuclear Ribonucleoprotein K

A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • hnRNP K
  • Heterogeneous Nuclear Ribonucleoprotein K
  • Ribonucleoprotein K, Heterogeneous-Nuclear
  • Heterogeneous Nuclear Ribonucleoprotein Particle K Protein
  • dC-Stretch-Binding Protein
  • hnRNP K Protein
  • dC Stretch Binding Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

see SCR for specific hnRNP entries

MeSH Record

History Note

2003; use HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K (NM) 1994-2002; for HNRNP K use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1994-2002

MeSH Record

Previous Indexing

  • DNA-Binding Proteins (1994-2002)
  • Ribonucleoproteins (1994-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.500w.313w.500
  2. D12.776w.157w.725w.813.750w.500
  3. D12.776w.260w.268
  4. D12.776w.664w.962w.500w.313w.500
  5. D12.776w.664w.962w.813.750w.500

AMA Style

References

  1. National Library of Medicine. Heterogeneous-Nuclear Ribonucleoprotein K. Medical Subject Headings (MeSH). 2026. Unique ID D034641. http://id.nlm.nih.gov/mesh/2026/D034641
  2. Heterogeneous-Nuclear Ribonucleoprotein K. In: Wikidata. https://www.wikidata.org/wiki/Q21142601