Diseases

Hereditary Spastic Paraplegia

A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

48 entry terms
  • Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia
  • Paraplegia, Spastic, Hereditary
  • Spastic Paraplegia, Hereditary
  • Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy
  • Hereditary Spastic Paraplegias
  • Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia
  • Paraplegia, Hereditary Spastic
  • Paraplegias, Hereditary Spastic
  • Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy
  • Spastic Paraplegias, Hereditary
  • Autosomal Dominant Hereditary Spastic Paraplegia
  • Autosomal Dominant Spastic Paraplegia Hereditary
  • Autosomal Recessive Hereditary Spastic Paraplegia
  • Autosomal Recessive Spastic Paraplegia
  • Autosomal Recessive Spastic Paraplegia, Hereditary
  • CMT with Pyramidal Features
  • Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant
  • HMSN 5
  • HMSN Type V
  • HMSN V
  • HMSN V (Hereditary Motor and Sensory Neuropathy Type V)
  • Hereditary Autosomal Dominant Spastic Paraplegia
  • Hereditary Autosomal Recessive Spastic Paraplegia
  • Hereditary Motor And Sensory Neuropathy V
  • Hereditary Motor and Sensory Neuropathy 5
  • Hereditary Motor-Sensory Neuropathy with Pyramidal Signs
  • Hereditary Spastic Paraplegia, Autosomal Recessive
  • Hereditary X-Linked Recessive Spastic Paraplegia
  • Hereditary, Spastic Paraplegia, Autosomal Dominant
  • Hereditary, Spastic Paraplegia, X-Linked Recessive
  • Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant
  • Spastic Paraplegia 2
  • Spastic Paraplegia Type 2
  • Spastic Paraplegia Type 5A, Recessive
  • Spastic Paraplegia, Autosomal Dominant, Hereditary
  • Spastic Paraplegia, Autosomal Recessive, Hereditary
  • Spastic Paraplegia, Hereditary, Autosomal Dominant
  • Spastic Paraplegia, Hereditary, Autosomal Recessive
  • Spastic Paraplegia, Hereditary, X-Linked Recessive
  • Spastic Paraplegia, X-Linked Recessive, Hereditary
  • Type V Hereditary Motor and Sensory Neuropathy
  • X Linked Recessive Hereditary Spastic Paraplegia
  • X-Linked, Spastic Paraplegia, Hereditary
  • X-linked Recessive Hereditary Spastic Paraplegia
  • Charcot Marie Tooth Disease with Pyramidal Features, Autosomal Dominant
  • Hereditary Motor Sensory Neuropathy with Pyramidal Signs
  • Hereditary X Linked Recessive Spastic Paraplegia
  • Type V, HMSN

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate with GENES, DOMINANT or GENES, RECESSIVE if discussed

MeSH Record

History Note

1991(1989)

MeSH Record

Previous Indexing

  • Muscle Spasticity/genetics (1975-1988)
  • Paraplegia/genetics (1966-1988)

MeSH Hierarchy

Tree Numbers

  1. C10w.500w.300w.820w
  2. C10w.574w.500.495w.820w
  3. C10w.668w.829w.800w.300w.820w
  4. C16w.131w.666w.300w.820w
  5. C16w.320w.400.375w.820w

MeSH Record

NLM Classification

WE 550

AMA Style

References

  1. National Library of Medicine. Hereditary Spastic Paraplegia. Medical Subject Headings (MeSH). 2026. Unique ID D015419. http://id.nlm.nih.gov/mesh/2026/D015419
  2. Hereditary Spastic Paraplegia. In: Wikipedia. https://en.wikipedia.org/wiki/Hereditary_spastic_paraplegia
  3. Hereditary Spastic Paraplegia. In: Wikidata. https://www.wikidata.org/wiki/Q657516