Phenomena and Processes

Helix-Loop-Helix Motifs

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical loop segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical loop segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.

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Synonyms

14 entry terms
  • HLH Motifs
  • Helix-Loop-Helix Domain
  • Helix-Loop-Helix Domains
  • Helix-Loop-Helix Motif
  • Motifs, Helix-Loop-Helix
  • HLH Motif
  • Helix Loop Helix Domain
  • Helix Loop Helix Domains
  • Helix Loop Helix Motif
  • Helix Loop Helix Motifs
  • Motif, HLH
  • Motif, Helix-Loop-Helix
  • Motifs, HLH
  • Motifs, Helix Loop Helix

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

do not confuse with HELIX-TURN-HELIX MOTIFS

MeSH Record

History Note

94

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1989-1993)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.500.360

AMA Style

References

  1. National Library of Medicine. Helix-Loop-Helix Motifs. Medical Subject Headings (MeSH). 2026. Unique ID D018257. http://id.nlm.nih.gov/mesh/2026/D018257
  2. Helix-Loop-Helix Motifs. In: Wikidata. https://www.wikidata.org/wiki/Q70683285