Phenomena and Processes

HMG-Box Domains

DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)

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Classification

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See Also

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Synonyms

12 entry terms
  • HMG-1-Box Domain
  • HMG-Box Domain
  • High Mobility Group-Box Domains
  • Domain, HMG-1-Box
  • Domain, HMG-Box
  • Domains, HMG-1-Box
  • Domains, HMG-Box
  • HMG 1 Box Domain
  • HMG Box Domain
  • HMG Box Domains
  • HMG-1-Box Domains
  • High Mobility Group Box Domains

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

HIGH MOBILITY GROUP PROTEINS is also available

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History Note

2002

MeSH Record

Previous Indexing

  • High Mobility Group Proteins (1991-2001)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.235w

AMA Style

References

  1. National Library of Medicine. HMG-Box Domains. Medical Subject Headings (MeSH). 2026. Unique ID D024742. http://id.nlm.nih.gov/mesh/2026/D024742
  2. HMG-Box Domains. In: Wikipedia. https://en.wikipedia.org/wiki/HMG-box
  3. HMG-Box Domains. In: Wikidata. https://www.wikidata.org/wiki/Q3782057