Chemicals and Drugs

HLA-E Antigens

Class I human histocompatibility (HLA) antigens encoded by genes at the E locus on chromosome 6. They bind a restricted subset of peptides derived from the leader peptides of other class I molecules. They primarily are involved with down-regulating cytolytic activity of NK CELLS and restricting non-canonical CD8-POSITIVE T LYMPHOCYTES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Class I human histocompatibility (HLA) antigens encoded by genes at the E locus on chromosome 6. They bind a restricted subset of peptides derived from the leader peptides of other class I molecules. They primarily are involved with down-regulating cytolytic activity of NK CELLS and restricting non-canonical CD8-POSITIVE T LYMPHOCYTES.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • HLA E Antigens
  • HLA E*0101 antigen
  • HLA-E 0103 antigen
  • HLA-E*0101 antigen
  • HLA-E*0103
  • HLA-E*01:01 antigen
  • HLA-E*01:03 antigen

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2024 (1988)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.489.850
  2. D12.776w.395w.550w.489.850
  3. D12.776w.543w.550w.439.850
  4. D23.050w.301.500.100.850
  5. D23.050w.705.552.100.850

AMA Style

References

  1. National Library of Medicine. HLA-E Antigens. Medical Subject Headings (MeSH). 2026. Unique ID D000097625. http://id.nlm.nih.gov/mesh/2026/D000097625
  2. HLA-E Antigens. In: Wikidata. https://www.wikidata.org/wiki/Q5630195