Chemicals and Drugs

HDL Lipoproteins

A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

16 entry terms
  • Heavy Lipoproteins
  • High Density Lipoprotein
  • High-Density Lipoprotein
  • High-Density Lipoproteins
  • Lipoproteins, HDL
  • alpha-Lipoprotein
  • alpha-Lipoproteins
  • Density Lipoprotein, High
  • High Density Lipoproteins
  • Lipoprotein, High Density
  • Lipoprotein, High-Density
  • Lipoproteins, Heavy
  • Lipoproteins, High-Density
  • alpha Lipoprotein
  • alpha Lipoproteins
  • alpha-1 Lipoprotein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

hyperalphalipoproteinemia = LIPOPROTEINS, HDL /blood (IM) + HYPERLIPOPROTEINEMIAS (IM); hypoalphalipoproteinemia = LIPOPROTEINS, HDL /blood (IM) + HYPOLIPOPROTEINEMIAS (IM); familial hypoalphalipoproteinemia = TANGIER DISEASE; /defic: consider also HYPOLIPOPROTEINEMIAS

MeSH Record

History Note

74(72)

MeSH Record

Previous Indexing

  • Lipoproteins (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.432w
  2. D12.776w.521w.479w

AMA Style

References

  1. National Library of Medicine. HDL Lipoproteins. Medical Subject Headings (MeSH). 2026. Unique ID D008075. http://id.nlm.nih.gov/mesh/2026/D008075
  2. HDL Lipoproteins. In: Wikipedia. https://en.wikipedia.org/wiki/High-density_lipoprotein
  3. HDL Lipoproteins. In: Wikidata. https://www.wikidata.org/wiki/Q410020