Chemicals and Drugs

Guanosine Pentaphosphate

Guanosine 5'-triphosphate 2'(3')-diphosphate. A guanine nucleotide containing five phosphate groups. Three phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Guanosine 5'-triphosphate 2'(3')-diphosphate. A guanine nucleotide containing five phosphate groups. Three phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

11 entry terms
  • (p)ppGpp
  • Alarmone pppGpp
  • Bacterial Magic Spot pppGpp
  • Guanosine 3'-Diphosphate 5'-Triphosphate
  • ppprGpp
  • 3'-Diphosphate 5'-Triphosphate, Guanosine
  • 5'-Triphosphate, Guanosine 3'-Diphosphate
  • Guanosine 3' Diphosphate 5' Triphosphate
  • Pentaphosphate, Guanosine
  • pppGpp, Alarmone
  • Alarmone

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(78); was see under GUANINE NUCLEOTIDES 1978-90

MeSH Record

Previous Indexing

  • Guanine Nucleotides (1966-1977)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Guanosine Pentaphosphate. Medical Subject Headings (MeSH). 2026. Unique ID D006158. http://id.nlm.nih.gov/mesh/2026/D006158
  2. Guanosine Pentaphosphate. In: Wikipedia. https://en.wikipedia.org/wiki/Guanosine_pentaphosphate
  3. Guanosine Pentaphosphate. In: Wikidata. https://www.wikidata.org/wiki/Q668231