Structured Summary
Abstract
A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.
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Synonyms
1 entry terms
- GDF-1
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30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2009(2005)
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References
- National Library of Medicine. Growth Differentiation Factor 1. Medical Subject Headings (MeSH). 2026. Unique ID D055452. http://id.nlm.nih.gov/mesh/2026/D055452
- Growth Differentiation Factor 1. In: Wikidata. https://www.wikidata.org/wiki/Q5513075