Structured Summary
Abstract
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
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Synonyms
8 entry terms
- Colony-Stimulating Factor, Granulocyte
- G-CSF
- Myeloid Growth Factor
- Colony Stimulating Factor, Granulocyte
- Factor, Granulocyte Colony-Stimulating
- Factor, Myeloid Growth
- Granulocyte Colony Stimulating Factor
- Growth Factor, Myeloid
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
91
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Previous Indexing
- Colony-Stimulating Factors (1976-1990)
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NLM Classification
WH 200
AMA Style
References
- National Library of Medicine. Granulocyte Colony-Stimulating Factor. Medical Subject Headings (MeSH). 2026. Unique ID D016179. http://id.nlm.nih.gov/mesh/2026/D016179
- Granulocyte Colony-Stimulating Factor. In: Wikidata. https://www.wikidata.org/wiki/Q50229794