Chemicals and Drugs

Granulocyte-Macrophage Colony-Stimulating Factor

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

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Classification

Broader headings

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See Also

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Synonyms

12 entry terms
  • CSF-2
  • CSF-GM
  • Colony-Stimulating Factor, Granulocyte-Macrophage
  • GM-CSF
  • Histamine-Producing Cell-Stimulating Factor
  • TC-GM-CSF
  • Tumor-Cell Human GM Colony-Stimulating Factor
  • Cell-Stimulating Factor, Histamine-Producing
  • Colony Stimulating Factor, Granulocyte Macrophage
  • Granulocyte Macrophage Colony Stimulating Factor
  • Histamine Producing Cell Stimulating Factor
  • Tumor Cell Human GM Colony Stimulating Factor

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91

MeSH Record

Previous Indexing

  • Colony-Stimulating Factors (1976-1990)
  • Growth Substances (1966-1990)
  • Interleukin-3 (1981-1987)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.775w.300
  2. D12.644w.276.374w.410.240w.375
  3. D12.776w.395w.240w.300
  4. D12.776w.467.374w.410.240w.375
  5. D23.529.374w.410.240w.375

AMA Style

References

  1. National Library of Medicine. Granulocyte-Macrophage Colony-Stimulating Factor. Medical Subject Headings (MeSH). 2026. Unique ID D016178. http://id.nlm.nih.gov/mesh/2026/D016178
  2. Granulocyte-Macrophage Colony-Stimulating Factor. In: Wikidata. https://www.wikidata.org/wiki/Q24724548