Chemicals and Drugs

Granisetron

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

Chemical Identity

Chemical Information

Molecular Formula
C18H24N4O
Molecular Weight
312.4 g/mol
CAS Registry No.
124998-65-8
IUPAC Name
1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide
InChIKey
MFWNKCLOYSRHCJ-UHFFFAOYSA-N
SMILES
CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
MeSH Unique ID
D017829
Source
PubChem CID 3510

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • 1-methyl-N-(endo-9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide
  • 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl
  • 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo-
  • BRL-43694
  • BRL-43694A
  • Granisetron Hydrochloride
  • Granisetron Monohydrochloride
  • Kytril
  • BRL 43694
  • BRL 43694A
  • BRL43694
  • BRL43694A
  • Hydrochloride, Granisetron
  • Monohydrochloride, Granisetron

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was GRANISETRON (NM) 1988-93

MeSH Record

Previous Indexing

  • Indazoles (1988-1993)

MeSH Hierarchy

Tree Numbers

  1. D02w.145.074.444w
  2. D03w.383.129w.539.487.350w
  3. D03w.605.084.500.444w
  4. D03w.633.100.449.350w

AMA Style

References

  1. National Library of Medicine. Granisetron. Medical Subject Headings (MeSH). 2026. Unique ID D017829. http://id.nlm.nih.gov/mesh/2026/D017829
  2. Granisetron. In: Wikipedia. https://en.wikipedia.org/wiki/Granisetron
  3. Granisetron. In: Wikidata. https://www.wikidata.org/wiki/Q596708
  4. Granisetron. In: PubChem Compound. CID 3510. https://pubchem.ncbi.nlm.nih.gov/compound/3510