Chemicals and Drugs

Goserelin

A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.

Chemical Identity

Chemical Information

Molecular Formula
C59H84N18O14
Molecular Weight
1269.4 g/mol
CAS Registry No.
65807-02-5
IUPAC Name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChIKey
BLCLNMBMMGCOAS-URPVMXJPSA-N
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6
MeSH Unique ID
D017273
Source
PubChem CID 5311128

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Goserelin Acetate
  • ICI-118630
  • Zoladex
  • Acetate, Goserelin
  • ICI 118630
  • ICI118630

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was ICI 118630 (NM) 1979-92

MeSH Record

Previous Indexing

  • Buserelin/analogs & derivatives (1984-1992)
  • Gonadorelin/analogs & derivatives (1979-1984)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.740.320w.340w
  2. D12.644w.400w.400.740.320w.340w
  3. D12.644w.456w.460w.315w
  4. D12.644w.548w.365.740.320w.340w
  5. D12.776w.631w.650w.405.740.320w.340w

AMA Style

References

  1. National Library of Medicine. Goserelin. Medical Subject Headings (MeSH). 2026. Unique ID D017273. http://id.nlm.nih.gov/mesh/2026/D017273
  2. Goserelin. In: Wikipedia. https://en.wikipedia.org/wiki/Goserelin
  3. Goserelin. In: Wikidata. https://www.wikidata.org/wiki/Q1992653
  4. Goserelin. In: PubChem Compound. CID 5311128. https://pubchem.ncbi.nlm.nih.gov/compound/5311128