Anatomy

Glymphatic System

A vascular waste clearance system in the brain analogous to the lymphatic system that facilitates transporting of solutes and waste products from CEREBROSPINAL FLUID (CSF) and brain INTERSTITIAL FLUID (ISF). CSF from the SUBARACHNOID SPACE enters the brain periarterial spaces, into the interstitium via channels (e.g., AQUAPORIN 4 PROTEIN) on astrocytic endfeet and exchanges with brain ISF before perivenous drainage of solutes and waste.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A vascular waste clearance system in the brain analogous to the lymphatic system that facilitates transporting of solutes and waste products from CEREBROSPINAL FLUID (CSF) and brain INTERSTITIAL FLUID (ISF). CSF from the SUBARACHNOID SPACE enters the brain periarterial spaces, into the interstitium via channels (e.g., AQUAPORIN 4 PROTEIN) on astrocytic endfeet and exchanges with brain ISF before perivenous drainage of solutes and waste.

MeSH Record

Classification

Related Concepts

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MeSH Record

Synonyms

14 entry terms
  • Glymphatic Clearance System
  • Glymphatic Pathway
  • Glymphatic Pathways
  • Pathway, Glymphatic
  • Brain Perivascular Space
  • Brain Perivascular Spaces
  • Meningeal Lymphatic Vessel
  • Meningeal Lymphatic Vessels
  • Virchow-Robin Space
  • Virchow-Robin Spaces
  • Lymphatic Vessel, Meningeal
  • Perivascular Space, Brain
  • Space, Virchow-Robin
  • Virchow Robin Space

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings abnormalities, anatomy & histology, chemistry, cytology, diagnostic imaging, drug effects, embryology, enzymology, growth & development, immunology, injuries, innervation, metabolism, microbiology, parasitology, pathology, physiology, physiopathology, radiation effects, surgery, transplantation, ultrastructure, virology.

MeSH Record

History Note

2019

MeSH Record

Previous Indexing

  • Lymphatic System (2013-2018)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Glymphatic System. Medical Subject Headings (MeSH). 2026. Unique ID D000077502. http://id.nlm.nih.gov/mesh/2026/D000077502
  2. Glymphatic System. In: Wikipedia. https://en.wikipedia.org/wiki/Glymphatic_system
  3. Glymphatic System. In: Wikidata. https://www.wikidata.org/wiki/Q15474254