Chemicals and Drugs

Glycogen Debranching Enzyme System

1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrolase. An enzyme system having both 4-alpha-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33) activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or another 1,4-alpha-D-glucan. As a glucosidase it catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-1,6-glucosidase activity is deficient in glycogen storage disease type III.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrolase. An enzyme system having both 4-alpha-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33) activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or another 1,4-alpha-D-glucan. As a glucosidase it catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-1,6-glucosidase activity is deficient in glycogen storage disease type III.

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Synonyms

5 entry terms
  • Transfer-Glucosidase
  • Transfer Glucosidase
  • Glycogen Debranching Enzyme
  • Debranching Enzyme, Glycogen
  • Enzyme, Glycogen Debranching

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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Indexing Annotation

/defic: consider also GLYCOGEN STORAGE DISEASE TYPE III

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History Note

89(76); was GLYCOGEN DEBRANCHING ENZYME see under GLUCOSYLTRANSFERASES 1976-88

MeSH Record

Previous Indexing

  • Glucosidase (1973-1975)
  • Glucosyltransferases (1973-1975)
  • Glycogen (1973-1975)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.450w.420w.450w
  2. D08.811w.913w.400w.450w.460w.350w

AMA Style

References

  1. National Library of Medicine. Glycogen Debranching Enzyme System. Medical Subject Headings (MeSH). 2026. Unique ID D006004. http://id.nlm.nih.gov/mesh/2026/D006004
  2. Glycogen Debranching Enzyme System. In: Wikipedia. https://en.wikipedia.org/wiki/Glycogen_debranching_enzyme
  3. Glycogen Debranching Enzyme System. In: Wikidata. https://www.wikidata.org/wiki/Q1532471