Chemicals and Drugs

Glutamate Receptors

Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases.

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Synonyms

6 entry terms
  • Glutamate Receptor
  • Receptors, Glutamate
  • Receptor, Glutamate
  • Excitatory Amino Acid Receptor
  • Excitatory Amino Acid Receptors
  • Receptors, Excitatory Amino Acid

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Aspects Covered

17 allowable subheadings

Indexed with the subheadings administration & dosage, analysis, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

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Indexing Annotation

general or unspecified; prefer specifics

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History Note

93; was GLUTAMATE RECEPTOR (NM) 1980-92; EXCITATORY AMINO ACID RECEPTORS & RECEPTORS, EXCITATORY AMINO ACID were see RECEPTORS, AMINO ACID 1993

MeSH Record

Previous Indexing

  • Receptors, Drug (1980-1981)
  • Receptors, Endogenous Substances (1980-1984)
  • Receptors, Synaptic (1980-1992)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.720w.200.450w

AMA Style

References

  1. National Library of Medicine. Glutamate Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D017470. http://id.nlm.nih.gov/mesh/2026/D017470
  2. Glutamate Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Glutamate_receptor
  3. Glutamate Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q420510