Chemicals and Drugs

Glutamate Plasma Membrane Transport Proteins

A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM ions. In the CENTRAL NERVOUS SYSTEM they regulate neurotransmission through synaptic reuptake of the excitatory neurotransmitter glutamate. Outside the central nervous system they function as signal mediators and regulators of glutamate metabolism.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM ions. In the CENTRAL NERVOUS SYSTEM they regulate neurotransmission through synaptic reuptake of the excitatory neurotransmitter glutamate. Outside the central nervous system they function as signal mediators and regulators of glutamate metabolism.

MeSH Record

Classification

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MeSH Record

Synonyms

15 entry terms
  • Glutamate Plasma Membrane Transporter Proteins
  • Neurotransmitter Transport Proteins, Glutamate-Specific
  • Neurotransmitter Transporters, Glutamate-Specific
  • Glutamate-Specific Neurotransmitter Transporters
  • Neurotransmitter Transport Proteins, Glutamate Specific
  • Neurotransmitter Transporters, Glutamate Specific
  • Transporters, Glutamate-Specific Neurotransmitter
  • EAAT Proteins
  • Excitatory Amino Acid Transport Proteins
  • Excitatory Amino Acid Transporter Proteins
  • Sodium-Glutamate Cotransporter
  • Sodium-Glutamate Transporter
  • Cotransporter, Sodium-Glutamate
  • Sodium Glutamate Cotransporter
  • Sodium Glutamate Transporter

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1984)

MeSH Record

Previous Indexing

  • Amino Acid Transport System X-AG (1984-2005)
  • Symporters (1984-2005)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.200.249.500.500w
  2. D12.776w.157w.530w.450w.625w.147w
  3. D12.776w.157w.530w.562w.374.781w
  4. D12.776w.157w.530w.937w.250.500w
  5. D12.776w.543w.585w.200.249.500.500w
  6. D12.776w.543w.585w.450w.625w.147w
  7. D12.776w.543w.585w.562w.374.781w
  8. D12.776w.543w.585w.937w.250.500w

AMA Style

References

  1. National Library of Medicine. Glutamate Plasma Membrane Transport Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D050491. http://id.nlm.nih.gov/mesh/2026/D050491
  2. Glutamate Plasma Membrane Transport Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Glutamate_transporter
  3. Glutamate Plasma Membrane Transport Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q5419641