Structured Summary
Abstract
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
7 entry terms
- Glutamate Carboxy-Lyase
- Glutamic Acid Decarboxylase
- Acid Decarboxylase, Glutamic
- Carboxy-Lyase, Glutamate
- Decarboxylase, Glutamate
- Decarboxylase, Glutamic Acid
- Glutamate Carboxy Lyase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
84(75); was see under CARBOXY-LYASES 1975-83
MeSH Record
Previous Indexing
- Carboxy-Lyases (1973-1974)
- Glutamates (1973-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Glutamate Decarboxylase. Medical Subject Headings (MeSH). 2026. Unique ID D005968. http://id.nlm.nih.gov/mesh/2026/D005968
- Glutamate Decarboxylase. In: Wikipedia. https://en.wikipedia.org/wiki/Glutamate_decarboxylase
- Glutamate Decarboxylase. In: Wikidata. https://www.wikidata.org/wiki/Q419650