Chemicals and Drugs

Glutamate-Cysteine Ligase

One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • Glutamylcysteine Synthetase
  • gamma-Glutamyl-Cysteine Synthetase
  • Glutamate Cysteine Ligase
  • Ligase, Glutamate-Cysteine
  • Synthetase, Glutamylcysteine
  • Synthetase, gamma-Glutamyl-Cysteine
  • gamma Glutamyl Cysteine Synthetase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

98(77)

MeSH Record

Previous Indexing

  • Cysteine (1973-1976)
  • Glutamates (1973-1976)
  • Peptide Synthetases (1973-1976)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Glutamate-Cysteine Ligase. Medical Subject Headings (MeSH). 2026. Unique ID D005721. http://id.nlm.nih.gov/mesh/2026/D005721
  2. Glutamate-Cysteine Ligase. In: Wikipedia. https://en.wikipedia.org/wiki/Glutamate%E2%80%93cysteine_ligase
  3. Glutamate-Cysteine Ligase. In: Wikidata. https://www.wikidata.org/wiki/Q908460