Chemicals and Drugs

Gliotoxin

A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.

Chemical Identity

Chemical Information

Molecular Formula
C13H14N2O4S2
Molecular Weight
326.4 g/mol
CAS Registry No.
67-99-2
IUPAC Name
(1R,7S,8S,11R)-7-hydroxy-11-(hydroxymethyl)-15-methyl-12,13-dithia-9,15-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,14-dione
InChIKey
FIVPIPIDMRVLAY-RBJBARPLSA-N
SMILES
CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O
MeSH Unique ID
D005912
Source
PubChem CID 6223

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Aspergillin
  • Gliotoxins

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/antag permitted but consider also ANTITOXINS;/biosyn permitted if by fungus

MeSH Record

History Note

96; was GLIOTOXINS 1981-95 (see under MYCOTOXINS 1981-90); was GLIOTOXIN see under ANTIBIOTICS 1975-80

MeSH Record

Previous Indexing

  • Alkaloids (1969-1974)
  • Disulfides (1973-1974)
  • Indoles (1969-1974)
  • Piperazines (1972-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.473.360w
  2. D23.946w.587w.401w

AMA Style

References

  1. National Library of Medicine. Gliotoxin. Medical Subject Headings (MeSH). 2026. Unique ID D005912. http://id.nlm.nih.gov/mesh/2026/D005912
  2. Gliotoxin. In: Wikipedia. https://en.wikipedia.org/wiki/Gliotoxin
  3. Gliotoxin. In: Wikidata. https://www.wikidata.org/wiki/Q413364
  4. Gliotoxin. In: PubChem Compound. CID 6223. https://pubchem.ncbi.nlm.nih.gov/compound/6223