Phenomena and Processes

Germ-Line Mutation

Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., generative cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., generative cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • Germline Mutation
  • Mutation, Germ-Line
  • Germ Line Mutation
  • Germ-Line Mutations
  • Germline Mutations
  • Mutation, Germ Line
  • Mutation, Germline
  • Mutations, Germ-Line
  • Mutations, Germline

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

germ-line refers to germ cells (ovum or spermatozoon), not micro-organisms

MeSH Record

History Note

94

MeSH Record

Previous Indexing

  • Mutation (1980-1993)

MeSH Hierarchy

Tree Number

  1. G05.365w.590w.350w

AMA Style

References

  1. National Library of Medicine. Germ-Line Mutation. Medical Subject Headings (MeSH). 2026. Unique ID D018095. http://id.nlm.nih.gov/mesh/2026/D018095
  2. Germ-Line Mutation. In: Wikipedia. https://en.wikipedia.org/wiki/Germline_mutation
  3. Germ-Line Mutation. In: Wikidata. https://www.wikidata.org/wiki/Q5552256