Chemicals and Drugs

Genistein

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

Chemical Identity

Chemical Information

Molecular Formula
C15H10O5
Molecular Weight
270.24 g/mol
CAS Registry No.
446-72-0
IUPAC Name
5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
InChIKey
TZBJGXHYKVUXJN-UHFFFAOYSA-N
SMILES
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
MeSH Unique ID
D019833
Source
PubChem CID 5280961

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Genestein

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use GENISTEIN (NM) 1980-97

MeSH Record

Previous Indexing

  • Isoflavones (1976-1997)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.663.283.266.450w.400w.375w
  2. D03w.633.100.150.266.450w.400w.375w

AMA Style

References

  1. National Library of Medicine. Genistein. Medical Subject Headings (MeSH). 2026. Unique ID D019833. http://id.nlm.nih.gov/mesh/2026/D019833
  2. Genistein. In: Wikipedia. https://en.wikipedia.org/wiki/Genistein
  3. Genistein. In: Wikidata. https://www.wikidata.org/wiki/Q415957
  4. Genistein. In: PubChem Compound. CID 5280961. https://pubchem.ncbi.nlm.nih.gov/compound/5280961