Structured Summary
Abstract
Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.
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Classification
Broader headings
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Synonyms
7 entry terms
- GS Inhibitors and Modulators
- GS Inhibitors
- GS Modulators
- Gamma Secretase Inhibitors
- Gamma Secretase Modulators
- Secretase Inhibitors, Gamma
- Secretase Modulators, Gamma
MeSH Record
Aspects Covered
22 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2022
MeSH Record
Previous Indexing
- Amyloid Precursor Protein Secretases (1995-2021)
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AMA Style
References
- National Library of Medicine. Gamma Secretase Inhibitors and Modulators. Medical Subject Headings (MeSH). 2026. Unique ID D000091062. http://id.nlm.nih.gov/mesh/2026/D000091062
- Gamma Secretase Inhibitors and Modulators. In: Wikidata. https://www.wikidata.org/wiki/Q1493181