Chemicals and Drugs

Gabexate

A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.

Chemical Identity

Chemical Information

Molecular Formula
C16H23N3O4
Molecular Weight
321.37 g/mol
CAS Registry No.
39492-01-8
IUPAC Name
ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate
InChIKey
YKGYIDJEEQRWQH-UHFFFAOYSA-N
SMILES
CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
MeSH Unique ID
D016670
Source
PubChem CID 3447

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Foy
  • Gabexate Mesilate
  • Gabexate Mesylate
  • Gabexate Methanesulfonate
  • Gabexate Monomethanesulfonate
  • Gabexate Monomethanesulfonate, 14C-Labeled Cpd
  • Gabexate Monomethanesulfonate, 14C Labeled Cpd
  • Mesilate, Gabexate
  • Mesylate, Gabexate
  • Methanesulfonate, Gabexate
  • Monomethanesulfonate, Gabexate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was GABEXATE (NM) 1976-91

MeSH Record

Previous Indexing

  • Anticoagulants (1966-1991)
  • Guanidines (1966-1991)
  • Protease Inhibitors (1979-1989)
  • Serine Proteinase Inhibitors (1990-1991)

MeSH Hierarchy

Tree Number

  1. D02w.078w.370.380w

AMA Style

References

  1. National Library of Medicine. Gabexate. Medical Subject Headings (MeSH). 2026. Unique ID D016670. http://id.nlm.nih.gov/mesh/2026/D016670
  2. Gabexate. In: Wikipedia. https://en.wikipedia.org/wiki/Gabexate
  3. Gabexate. In: Wikidata. https://www.wikidata.org/wiki/Q5515384
  4. Gabexate. In: PubChem Compound. CID 3447. https://pubchem.ncbi.nlm.nih.gov/compound/3447