Chemicals and Drugs

GTP Pyrophosphokinase

An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • ATP-Guanosine Phosphate Pyrophosphotransferase
  • Stringent Factor
  • ATP Guanosine Phosphate Pyrophosphotransferase
  • Factor, Stringent
  • Pyrophosphokinase, GTP
  • Pyrophosphotransferase, ATP-Guanosine Phosphate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

92; was ATP-GUANOSINE PHOSPHATE PYROPHOSPHOTRANSFERASE 1980-91 (see under PHOSPHOTRANSFERASES, ATP 1980-90)

MeSH Record

Previous Indexing

  • Adenosine Triphosphate (1966-1979)
  • Bacterial Proteins (1966-1979)
  • Guanine Nucleotides (1966-1979)
  • Phosphotransferases (1966-1973)
  • Phosphotransferases, ATP (1974-1979)
  • Pyrophosphates (1966-1979)
  • Ribosomal Proteins (1975-1979)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.175w.300

AMA Style

References

  1. National Library of Medicine. GTP Pyrophosphokinase. Medical Subject Headings (MeSH). 2026. Unique ID D001277. http://id.nlm.nih.gov/mesh/2026/D001277
  2. GTP Pyrophosphokinase. In: Wikidata. https://www.wikidata.org/wiki/Q76851053