Structured Summary
Abstract
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
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Classification
Broader headings
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Synonyms
16 entry terms
- 7,8-Dihydroneopterintriphosphate Synthetase
- GTP 8-Formylhydrolase
- GTP Dihydrolase
- GTP Ring-Opening Enzyme
- 7,8 Dihydroneopterintriphosphate Synthetase
- 8-Formylhydrolase, GTP
- Cyclohydrolase, GTP
- Dihydrolase, GTP
- GTP 8 Formylhydrolase
- GTP Ring Opening Enzyme
- Ring-Opening Enzyme, GTP
- Synthetase, 7,8-Dihydroneopterintriphosphate
- GTP Cyclohydrolase I
- GTP Cyclohydrolase II
- Cyclohydrolase I, GTP
- Cyclohydrolase II, GTP
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
91(75); was see under AMINOHYDROLASES 1975-90
MeSH Record
Previous Indexing
- Aminohydrolases (1974)
- Guanosine Triphosphate (1974)
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AMA Style
References
- National Library of Medicine. GTP Cyclohydrolase. Medical Subject Headings (MeSH). 2026. Unique ID D006136. http://id.nlm.nih.gov/mesh/2026/D006136
- GTP Cyclohydrolase. In: Wikidata. https://www.wikidata.org/wiki/Q76709959