Chemicals and Drugs

GTP-Binding Protein alpha Subunits

The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.

MeSH Record

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MeSH Record

Synonyms

6 entry terms
  • G-Protein alpha Subunit
  • GTP-Binding Protein alpha Subunit
  • G Protein alpha Subunit
  • GTP Binding Protein alpha Subunit
  • GTP Binding Protein alpha Subunits
  • alpha Subunit, G-Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use HETEROTRIMERIC GTP-BINDING PROTEINS 2001-2003

MeSH Record

Previous Indexing

  • Heterotrimeric GTP-Binding Proteins (2000-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.330.300.200w.100w
  2. D12.776w.157w.325.332w.100w
  3. D12.776w.476.338.200w.100w
  4. D12.776w.543w.325w.100w

AMA Style

References

  1. National Library of Medicine. GTP-Binding Protein alpha Subunits. Medical Subject Headings (MeSH). 2026. Unique ID D044385. http://id.nlm.nih.gov/mesh/2026/D044385
  2. GTP-Binding Protein alpha Subunits. In: Wikipedia. https://en.wikipedia.org/wiki/G_alpha_subunit
  3. GTP-Binding Protein alpha Subunits. In: Wikidata. https://www.wikidata.org/wiki/Q24778884