Chemicals and Drugs

G(M2) Ganglioside

A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), or GM2 activator protein, resulting in GANGLIOSIDOSES, heredity metabolic disorders that include TAY-SACHS DISEASE and SANDHOFF DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), or GM2 activator protein, resulting in GANGLIOSIDOSES, heredity metabolic disorders that include TAY-SACHS DISEASE and SANDHOFF DISEASE.

Chemical Identity

Chemical Information

Molecular Formula
C67H121N3O26
Molecular Weight
1384.7 g/mol
CAS Registry No.
127663-77-8
IUPAC Name
(2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2S,3R)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
InChIKey
GIVLTTJNORAZON-HDBOBKCLSA-N
SMILES
CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(=O)C)O[C@@]4(C[C@@H]([C@H]([C@@H](O4)[C@@H]([C@@H](CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)[C@@H](/C=C/CCCCCCCCCCCCC)O
MeSH Unique ID
D005678
Source
PubChem CID 9898635

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • GM2 Ganglioside
  • Ganglioside GM2
  • Tay-Sachs Disease Ganglioside
  • GM2, Ganglioside
  • Ganglioside, GM2
  • Ganglioside, Tay-Sachs Disease
  • Tay Sachs Disease Ganglioside

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under GANGLIOSIDES 1975-90

MeSH Record

Previous Indexing

  • Gangliosides (1974)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.410w.420w.025.475w.400w
  2. D10w.390w.470w.025.475w.400w
  3. D10w.570w.877w.360w.025.475w.400w

AMA Style

References

  1. National Library of Medicine. G(M2) Ganglioside. Medical Subject Headings (MeSH). 2026. Unique ID D005678. http://id.nlm.nih.gov/mesh/2026/D005678
  2. G(M2) Ganglioside. In: Wikipedia. https://en.wikipedia.org/wiki/GM2_(ganglioside)
  3. G(M2) Ganglioside. In: Wikidata. https://www.wikidata.org/wiki/Q5513693
  4. G(M2) Ganglioside. In: PubChem Compound. CID 9898635. https://pubchem.ncbi.nlm.nih.gov/compound/9898635