Chemicals and Drugs

G(M1) Ganglioside

A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.

Chemical Identity

Chemical Information

Molecular Formula
C73H131N3O31
Molecular Weight
1546.8 g/mol
CAS Registry No.
116950-37-9
IUPAC Name
(2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2S,3R)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
InChIKey
QPJBWNIQKHGLAU-IQZHVAEDSA-N
SMILES
CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)NC(=O)C)O[C@@]5(C[C@@H]([C@H]([C@@H](O5)[C@@H]([C@@H](CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)[C@@H](/C=C/CCCCCCCCCCCCC)O
MeSH Unique ID
D005677
Source
PubChem CID 9963963

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

7 entry terms
  • GM1 Ganglioside
  • Monosialosyl Tetraglycosyl Ceramide
  • Ceramide, Monosialosyl Tetraglycosyl
  • Ganglioside, GM1
  • Tetraglycosyl Ceramide, Monosialosyl
  • GM1a Monosialoganglioside
  • Monosialoganglioside, GM1a

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

86(77); was see under GANGLIOSIDES 1977-85

MeSH Record

Previous Indexing

  • Gangliosides (1966-1976)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.410w.420w.025.475w.390
  2. D10w.390w.470w.025.475w.390
  3. D10w.570w.877w.360w.025.475w.390

AMA Style

References

  1. National Library of Medicine. G(M1) Ganglioside. Medical Subject Headings (MeSH). 2026. Unique ID D005677. http://id.nlm.nih.gov/mesh/2026/D005677
  2. G(M1) Ganglioside. In: Wikidata. https://www.wikidata.org/wiki/Q27130590
  3. G(M1) Ganglioside. In: PubChem Compound. CID 9963963. https://pubchem.ncbi.nlm.nih.gov/compound/9963963