Chemicals and Drugs

GABA Receptors

Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.

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Synonyms

10 entry terms
  • GABA Receptor
  • Receptors, GABA
  • Receptors, gamma-Aminobutyric Acid
  • gamma-Aminobutyric Acid Receptor
  • gamma-Aminobutyric Acid Receptors
  • Receptor, GABA
  • Receptor, gamma-Aminobutyric Acid
  • Receptors, gamma Aminobutyric Acid
  • gamma Aminobutyric Acid Receptor
  • gamma Aminobutyric Acid Receptors

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Aspects Covered

17 allowable subheadings

Indexed with the subheadings administration & dosage, analysis, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

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History Note

94; GABA RECEPTORS & RECEPTORS, GAMMA-AMINOBUTYRIC ACID were see RECEPTORS, GABA-BENZODIAZEPINE 1985-93

MeSH Record

Previous Indexing

  • GABA (1979-1984)
  • Receptors, Cell Surface (1973-1984)
  • Receptors, GABA-A (1985-1993)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.720w.200.300w

MeSH Record

NLM Classification

QU 60

AMA Style

References

  1. National Library of Medicine. GABA Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D018079. http://id.nlm.nih.gov/mesh/2026/D018079
  2. GABA Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/GABA_receptor
  3. GABA Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q306252