Chemicals and Drugs

Fusion Regulatory Protein-1

A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (FUSION REGULATORY PROTEIN 1, HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (FUSION REGULATORY PROTEIN 1, LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (FUSION REGULATORY PROTEIN 1, HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (FUSION REGULATORY PROTEIN 1, LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.

MeSH Record

Classification

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MeSH Record

Synonyms

19 entry terms
  • 4F2 Antigen
  • 4F2-antigen
  • Antigen 4F2
  • Antigens, CD98
  • CD98 Antigen
  • CD98 Antigens
  • CD98 Transport Proteins
  • FRP-1 protein
  • Antigen, CD98
  • FRP 1 protein
  • Fusion Regulatory Protein 1
  • Regulatory Protein-1, Fusion
  • Transport Proteins, CD98
  • H4F2 Antigen
  • Human 4F2 Antigen
  • Human 4F2 Cell-Surface Antigen
  • Human Lymphocyte Activation Antigen 4F2
  • 4F2 Antigen, Human
  • Human 4F2 Cell Surface Antigen

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1988)

MeSH Record

Previous Indexing

  • Antigens, CD (1996-2001)
  • Antigens, Surface (1989-1995)
  • Carrier Proteins (1996-2001)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.200.374.750.500w
  2. D12.776w.157w.530w.200.500.500.500w
  3. D12.776w.157w.530w.937w.313.500w
  4. D12.776w.543w.585w.200.374.750.500w
  5. D12.776w.543w.585w.200.500.500.500w
  6. D12.776w.543w.585w.937w.313.500w

AMA Style

References

  1. National Library of Medicine. Fusion Regulatory Protein-1. Medical Subject Headings (MeSH). 2026. Unique ID D027261. http://id.nlm.nih.gov/mesh/2026/D027261
  2. Fusion Regulatory Protein-1. In: Wikipedia. https://en.wikipedia.org/wiki/CD98
  3. Fusion Regulatory Protein-1. In: Wikidata. https://www.wikidata.org/wiki/Q5009853