Diseases

Frontotemporal Lobar Degeneration

Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

7 entry terms
  • FTLD
  • Degeneration, Frontotemporal Lobar
  • Degenerations, Frontotemporal Lobar
  • FTLDs
  • Frontotemporal Lobar Degenerations
  • Lobar Degeneration, Frontotemporal
  • Lobar Degenerations, Frontotemporal

MeSH Record

Aspects Covered

31 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, rehabilitation, surgery, therapy, urine, virology.

MeSH Record

History Note

2010; use DEMENTIA 2000-2009; for SEMANTIC DEMENTIA use DEMENTIA 2000-2009

MeSH Record

Previous Indexing

  • Dementia (2002-2009)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.380w.266w
  2. C10w.574w.950.300w
  3. C18.452w.845.800.300w
  4. F03w.615w.400w.380w

AMA Style

References

  1. National Library of Medicine. Frontotemporal Lobar Degeneration. Medical Subject Headings (MeSH). 2026. Unique ID D057174. http://id.nlm.nih.gov/mesh/2026/D057174
  2. Frontotemporal Lobar Degeneration. In: Wikipedia. https://en.wikipedia.org/wiki/Frontotemporal_lobar_degeneration
  3. Frontotemporal Lobar Degeneration. In: Wikidata. https://www.wikidata.org/wiki/Q18579