Chemicals and Drugs

Frataxin

A protein involved in the transfer of iron and sulfur to iron-sulfur cluster (ISC) assembly complex for de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. Deficiency leads to the neurodegenerative disease FRIEDREICH ATAXIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein involved in the transfer of iron and sulfur to iron-sulfur cluster (ISC) assembly complex for de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. Deficiency leads to the neurodegenerative disease FRIEDREICH ATAXIA.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • FXN Frataxin
  • Frataxin Protein
  • Friedreich Ataxia Protein
  • Ataxia Protein, Friedreich
  • Frataxin, FXN
  • Protein, Frataxin
  • Protein, Friedreich Ataxia

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2024 (1996)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.427w.374w.375w.959
  2. D12.776w.556w.579w.374w.375w.789
  3. D12.776w.575.609

AMA Style

References

  1. National Library of Medicine. Frataxin. Medical Subject Headings (MeSH). 2026. Unique ID D000096923. http://id.nlm.nih.gov/mesh/2026/D000096923
  2. Frataxin. In: Wikidata. https://www.wikidata.org/wiki/Q24776488