Chemicals and Drugs

Fosinopril

A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.

Chemical Identity

Chemical Information

Molecular Formula
C30H46NO7P
Molecular Weight
563.7 g/mol
CAS Registry No.
474519-28-3
IUPAC Name
(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
InChIKey
BIDNLKIUORFRQP-FKDWWROVSA-N
SMILES
CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)O)C3CCCCC3
MeSH Unique ID
D017328
Source
PubChem CID 55891

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

23 entry terms
  • Fosenopril
  • Dynacil
  • Fosinil
  • Fosinopril Sodium
  • Fosinopril, (1(S*(R*)),2 alpha,4 alpha)-(D-Pro)-Isomer
  • Fosinopril, (1(S*(R*)),2 alpha,4 beta)-Isomer
  • Fosinopril, (1(S*(S*)),2 alpha,4 beta)-Isomer
  • Fosinorm
  • Fositens
  • Fozitec
  • Hiperlex
  • Monopril
  • Newace
  • SQ-28,555
  • SQ-28555
  • Staril
  • Tenso Stop
  • Tensocardil
  • SQ 28,555
  • SQ 28555
  • SQ28,555
  • SQ28555
  • Sodium, Fosinopril

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was FOSENOPRIL (NM) 1985-92

MeSH Record

Previous Indexing

  • Proline/analogs & derivatives (1985-1992)

MeSH Hierarchy

Tree Numbers

  1. D02w.705w.629.500w
  2. D12.125w.072.401w.623w.374w

AMA Style

References

  1. National Library of Medicine. Fosinopril. Medical Subject Headings (MeSH). 2026. Unique ID D017328. http://id.nlm.nih.gov/mesh/2026/D017328
  2. Fosinopril. In: Wikipedia. https://en.wikipedia.org/wiki/Fosinopril
  3. Fosinopril. In: Wikidata. https://www.wikidata.org/wiki/Q425293
  4. Fosinopril. In: PubChem Compound. CID 55891. https://pubchem.ncbi.nlm.nih.gov/compound/55891