Structured Summary
Abstract
A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.
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Classification
Broader headings
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MeSH Record
Synonyms
4 entry terms
- FOXO3 Protein
- Forkhead in Rhabdomyosarcoma-Like 1 Protein
- Forkhead in Rhabdomyosarcoma Like 1 Protein
- Protein, FOXO3
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Forkhead Transcription Factors (2006-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Forkhead Box Protein O3. Medical Subject Headings (MeSH). 2026. Unique ID D000071316. http://id.nlm.nih.gov/mesh/2026/D000071316
- Forkhead Box Protein O3. In: Wikipedia. https://en.wikipedia.org/wiki/FOXO3
- Forkhead Box Protein O3. In: Wikidata. https://www.wikidata.org/wiki/Q21101484