Structured Summary
Abstract
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
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Classification
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Synonyms
13 entry terms
- Flap Endonuclease
- Endonuclease, Flap
- Endonucleases, Flap
- FEN-1
- Fen1 Protein
- Flap Endonuclease-1
- RAD2 Homolog-1 Nuclease
- RTH-1 Nuclease
- Endonuclease-1, Flap
- Flap Endonuclease 1
- Nuclease, RTH-1
- RAD2 Homolog 1 Nuclease
- RTH 1 Nuclease
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003
MeSH Record
Previous Indexing
- Endodeoxyribonucleases (1994-2003)
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References
- National Library of Medicine. Flap Endonucleases. Medical Subject Headings (MeSH). 2026. Unique ID D045585. http://id.nlm.nih.gov/mesh/2026/D045585
- Flap Endonucleases. In: Wikipedia. https://en.wikipedia.org/wiki/Flap_endonuclease
- Flap Endonucleases. In: Wikidata. https://www.wikidata.org/wiki/Q54462031