Chemicals and Drugs

First Generation Cephalosporins

CEPHALOSPORIN agents with excellent coverage against gram-positive cocci, such as STAPHYLOCOCCUS and STREPTOCOCCUS. They have some activity against the gram-negative bacteria, but in general, gram-negative activity is decreased compared to 2nd, 3rd, and 4th generation cephalosporins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

CEPHALOSPORIN agents with excellent coverage against gram-positive cocci, such as STAPHYLOCOCCUS and STREPTOCOCCUS. They have some activity against the gram-negative bacteria, but in general, gram-negative activity is decreased compared to 2nd, 3rd, and 4th generation cephalosporins.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • First Generation Cephalosporin
  • Cephalosporin, First Generation
  • Cephalosporins, First Generation
  • Generation Cephalosporin, First

MeSH Record

Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2024

MeSH Record

Previous Indexing

  • Cephalosporins (1981-2023)

MeSH Hierarchy

Tree Number

  1. D27.505.954.122.085w.386w.500

AMA Style

References

  1. National Library of Medicine. First Generation Cephalosporins. Medical Subject Headings (MeSH). 2026. Unique ID D000097904. http://id.nlm.nih.gov/mesh/2026/D000097904
  2. First Generation Cephalosporins. In: Wikidata. https://www.wikidata.org/wiki/Q124342364