Structured Summary
Abstract
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
24 entry terms
- Filamin
- 280 kDa Actin-Binding Protein
- Filamin 1
- Filamin 1-Like Protein
- Filamin A
- Filamin B
- Filamin C
- Merofilamins
- alpha-Filamin
- beta-Filamin
- 1-Like Protein, Filamin
- 1-Like Proteins, Filamin
- 280 kDa Actin Binding Protein
- Cs, Filamin
- Filamin 1 Like Protein
- Filamin 1-Like Proteins
- Filamin Cs
- Merofilamin
- Protein, Filamin 1-Like
- Proteins, Filamin 1-Like
- alpha Filamin
- alpha-Filamins
- beta Filamin
- beta-Filamins
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2014
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Filamins. Medical Subject Headings (MeSH). 2026. Unique ID D064448. http://id.nlm.nih.gov/mesh/2026/D064448
- Filamins. In: Wikipedia. https://en.wikipedia.org/wiki/Filamin
- Filamins. In: Wikidata. https://www.wikidata.org/wiki/Q410803