Chemicals and Drugs

Fibroblast Growth Factors

A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.

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Synonyms

5 entry terms
  • DNA Synthesis Factor
  • Fibroblast Growth Factor
  • Fibroblast Growth Regulatory Factor
  • Growth Factor, Fibroblast
  • Growth Factors, Fibroblast

MeSH Record

Aspects Covered

31 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2001(1984)

MeSH Record

Previous Indexing

  • Fibroblasts (1974-1983)
  • Growth Substances (1974-1983)
  • Mitogens (1974-1983)
  • Nerve Tissue Proteins (1974-1983)
  • Peptides (1974-1983)
  • Pituitary Hormones (1974-1983)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.624w
  2. D12.776w.467.624w
  3. D23.529.624w

MeSH Record

NLM Classification

QU 107

AMA Style

References

  1. National Library of Medicine. Fibroblast Growth Factors. Medical Subject Headings (MeSH). 2026. Unique ID D005346. http://id.nlm.nih.gov/mesh/2026/D005346
  2. Fibroblast Growth Factors. In: Wikipedia. https://en.wikipedia.org/wiki/Fibroblast_growth_factor
  3. Fibroblast Growth Factors. In: Wikidata. https://www.wikidata.org/wiki/Q24727126