Chemicals and Drugs

Fibrin Tissue Adhesive

An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

25 entry terms
  • Autologous Fibrin Tissue Adhesive
  • Fibrin Adhesive
  • Fibrin Glue
  • Fibrin Sealant
  • Fibrin Sealant System
  • Fibrinogen Adhesive
  • Adhesive, Fibrin
  • Adhesive, Fibrin Tissue
  • Adhesive, Fibrinogen
  • Glue, Fibrin
  • Sealant System, Fibrin
  • Sealant, Fibrin
  • Tissue Adhesive, Fibrin
  • Beriplast
  • Crosseal
  • Fibrin Klebe System Immuno
  • Fibrin Seal
  • Fibrin Sealant, Human
  • Tisseel
  • Tissel
  • Tissucol
  • Transglutine
  • Human Fibrin Sealant
  • Seal, Fibrin
  • Sealant, Human Fibrin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Factor VIII (1966-1989)
  • Fibrinogen (1966-1969)
  • Hemostatics (1966-1989)
  • Thrombin (1966-1989)

MeSH Hierarchy

Tree Number

  1. D12.776w.124w.270w.305w

AMA Style

References

  1. National Library of Medicine. Fibrin Tissue Adhesive. Medical Subject Headings (MeSH). 2026. Unique ID D015718. http://id.nlm.nih.gov/mesh/2026/D015718
  2. Fibrin Tissue Adhesive. In: Wikipedia. https://en.wikipedia.org/wiki/Fibrin_glue
  3. Fibrin Tissue Adhesive. In: Wikidata. https://www.wikidata.org/wiki/Q1410780