Structured Summary
Abstract
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
See Also
MeSH Record
Synonyms
10 entry terms
- Heme Synthetase
- Porphyrin-Metal Chelatase
- Protoheme Ferro-Lyase
- Chelatase, Porphyrin-Metal
- Ferro-Lyase, Protoheme
- Porphyrin Metal Chelatase
- Protoheme Ferro Lyase
- Synthetase, Heme
- Zinc Chelatase
- Chelatase, Zinc
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
1991(1977); use LYASES 1977-1990
MeSH Record
Previous Indexing
- Iron (1966-1976)
- Lyases (1966-1976)
- Porphyrins (1966-1976)
- Protoporphyrins (1975-1976)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Ferrochelatase. Medical Subject Headings (MeSH). 2026. Unique ID D005294. http://id.nlm.nih.gov/mesh/2026/D005294
- Ferrochelatase. In: Wikidata. https://www.wikidata.org/wiki/Q24770752