Chemicals and Drugs

Farnesyl-Diphosphate Farnesyltransferase

The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

16 entry terms
  • FPP-FPP Farnesyl Transferase
  • Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
  • Presqualene-Diphosphate Synthase
  • Squalene Synthase
  • Squalene Synthetase
  • FPP FPP Farnesyl Transferase
  • Farnesyl Diphosphate Farnesyltransferase
  • Farnesyl Transferase, FPP-FPP
  • Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase
  • Farnesyltransferase, Farnesyl-Diphosphate
  • Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate
  • Presqualene Diphosphate Synthase
  • Synthase, Presqualene-Diphosphate
  • Synthase, Squalene
  • Synthetase, Squalene
  • Transferase, FPP-FPP Farnesyl

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1975)

MeSH Record

Previous Indexing

  • Farnesol (1972-1974)
  • Ligases (1972-1974)
  • Pyrophosphoric Acids (1972-1974)
  • Squalene (1972-1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.225.431w

AMA Style

References

  1. National Library of Medicine. Farnesyl-Diphosphate Farnesyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D013186. http://id.nlm.nih.gov/mesh/2026/D013186
  2. Farnesyl-Diphosphate Farnesyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Farnesyl-diphosphate_farnesyltransferase
  3. Farnesyl-Diphosphate Farnesyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q410600