Chemicals and Drugs

Fanconi Anemia Complementation Group N Protein

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

3 entry terms
  • FANCN Protein
  • PALB2 Protein
  • Partner and Localizer of BRCA2 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Nuclear Proteins (2006-2017)
  • Tumor Suppressor Proteins (2006-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.313.953
  2. D12.776w.624.776.051
  3. D12.776w.660w.323

AMA Style

References

  1. National Library of Medicine. Fanconi Anemia Complementation Group N Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000076164. http://id.nlm.nih.gov/mesh/2026/D000076164
  2. Fanconi Anemia Complementation Group N Protein. In: Wikidata. https://www.wikidata.org/wiki/Q83138829