Chemicals and Drugs

Eukaryotic Initiation Factor-5

A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • EIF-5
  • Eukaryotic Peptide Initiation Factor-5
  • Peptide Initiation Factor EIF-5
  • Eukaryotic Initiation Factor 5
  • Eukaryotic Peptide Initiation Factor 5
  • Initiation Factor-5, Eukaryotic
  • Peptide Initiation Factor EIF 5

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use EUKARYOTIC INITIATION FACTOR-5 (NM) 1982-2002

MeSH Record

Previous Indexing

  • Peptide Initiation Factors (1982-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.325w.150w.300
  2. D12.776w.476.325w.150w.300
  3. D12.776w.835w.725w.868w.750

AMA Style

References

  1. National Library of Medicine. Eukaryotic Initiation Factor-5. Medical Subject Headings (MeSH). 2026. Unique ID D040061. http://id.nlm.nih.gov/mesh/2026/D040061
  2. Eukaryotic Initiation Factor-5. In: Wikidata. https://www.wikidata.org/wiki/Q21171046