Chemicals and Drugs

Eukaryotic Initiation Factor-3

A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the site of transcription initiation by promoting the dissociation of non-translating ribosomal subunits. It also is involved in promoting the binding of a ternary complex of EUKARYOTIC INITIATION FACTOR-2; GTP; and INITIATOR TRNA to the 40S ribosomal subunit.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the site of transcription initiation by promoting the dissociation of non-translating ribosomal subunits. It also is involved in promoting the binding of a ternary complex of EUKARYOTIC INITIATION FACTOR-2; GTP; and INITIATOR TRNA to the 40S ribosomal subunit.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

69 entry terms
  • EIF-3
  • EIF3
  • Eukaryotic Peptide Initiation Factor-3
  • Peptide Initiation Factor EIF-3
  • Eukaryotic Initiation Factor 3
  • Eukaryotic Peptide Initiation Factor 3
  • Initiation Factor-3, Eukaryotic
  • Peptide Initiation Factor EIF 3
  • EIF3 p110
  • EIF3 p42 Protein
  • EIF3-alpha
  • EIF3-beta
  • EIF3-epsilon
  • EIF3-gamma
  • EIF3-p48
  • EIF3-zeta
  • EIF3S3 Gene Product
  • EIF3S3 Protein
  • EIF3S4 Protein
  • Eukaryotic Initiation Factor-3 p110
  • Eukaryotic Initiation Factor-3, Subunit 1
  • Eukaryotic Initiation Factor-3, Subunit 2
  • Eukaryotic Initiation Factor-3, Subunit 3
  • Eukaryotic Initiation Factor-3, Subunit 4
  • Eukaryotic Initiation Factor-3, Subunit 5
  • Eukaryotic Initiation Factor-3, Subunit 6
  • Eukaryotic Initiation Factor-3, Subunit 7
  • Eukaryotic Initiation Factor-3, Subunit 8
  • Eukaryotic Initiation Factor-3, beta Subunit
  • Eukaryotic Initiation Factor-3, delta Subunit
  • Eukaryotic Initiation Factor-3, gamma Subunit
  • Eukaryotic Initiation Factor-3, zeta Subunit
  • Eukaryotic Peptide Initiation Factor 3, Subunit 5
  • Eukaryotic Peptide Initiation Factor-3, Subunit 1
  • Eukaryotic Peptide Initiation Factor-3, Subunit 2
  • Eukaryotic Peptide Initiation Factor-3, Subunit 3
  • Eukaryotic Peptide Initiation Factor-3, Subunit 4
  • Eukaryotic Peptide Initiation Factor-3, alpha Subunit
  • Eukaryotic Translation Initiation Factor-3, Subunit 8
  • INT6 Protein
  • Int-6 Gene Product
  • Int-6 Protein
  • p42 EIF3 Protein
  • EIF3 Protein, p42
  • EIF3 alpha
  • EIF3 epsilon
  • EIF3 gamma
  • Eukaryotic Initiation Factor 3 p110
  • Eukaryotic Initiation Factor 3, Subunit 1
  • Eukaryotic Initiation Factor 3, Subunit 2
  • Eukaryotic Initiation Factor 3, Subunit 3
  • Eukaryotic Initiation Factor 3, Subunit 4
  • Eukaryotic Initiation Factor 3, Subunit 5
  • Eukaryotic Initiation Factor 3, Subunit 6
  • Eukaryotic Initiation Factor 3, Subunit 7
  • Eukaryotic Initiation Factor 3, Subunit 8
  • Eukaryotic Initiation Factor 3, beta Subunit
  • Eukaryotic Initiation Factor 3, delta Subunit
  • Eukaryotic Initiation Factor 3, gamma Subunit
  • Eukaryotic Initiation Factor 3, zeta Subunit
  • Eukaryotic Peptide Initiation Factor 3, Subunit 1
  • Eukaryotic Peptide Initiation Factor 3, Subunit 2
  • Eukaryotic Peptide Initiation Factor 3, Subunit 3
  • Eukaryotic Peptide Initiation Factor 3, Subunit 4
  • Eukaryotic Peptide Initiation Factor 3, alpha Subunit
  • Eukaryotic Translation Initiation Factor 3, Subunit 8
  • Gene Product, Int-6
  • Int 6 Gene Product
  • Int 6 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use EUKARYOTIC INITIATION FACTOR-3 (NM) 1990-2002

MeSH Record

Previous Indexing

  • Peptide Initiation Factors (1990-2002)

MeSH Hierarchy

Tree Number

  1. D12.776w.835w.725w.868w.437w

AMA Style

References

  1. National Library of Medicine. Eukaryotic Initiation Factor-3. Medical Subject Headings (MeSH). 2026. Unique ID D039621. http://id.nlm.nih.gov/mesh/2026/D039621
  2. Eukaryotic Initiation Factor-3. In: Wikipedia. https://en.wikipedia.org/wiki/Eukaryotic_initiation_factor_3
  3. Eukaryotic Initiation Factor-3. In: Wikidata. https://www.wikidata.org/wiki/Q21836981