Chemicals and Drugs

Eukaryotic Initiation Factor-2

Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.

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Classification

Broader headings

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MeSH Record

Synonyms

27 entry terms
  • EIF-2
  • EIF2
  • Eukaryotic Peptide Initiation Factor-2
  • Peptide Initiation Factor EIF-2
  • EIF 2
  • Eukaryotic Initiation Factor 2
  • Eukaryotic Peptide Initiation Factor 2
  • Initiation Factor-2, Eukaryotic
  • Peptide Initiation Factor EIF 2
  • EIF-2 alpha
  • EIF-2 beta
  • EIF-2 gamma
  • EIF-2alpha
  • EIF-2beta
  • EIF-2gamma
  • Eukaryotic Initiation Factor-2, alpha Subunit
  • Eukaryotic Initiation Factor-2, beta Subunit
  • Eukaryotic Initiation Factor-2, gamma Subunit
  • EIF 2 alpha
  • EIF 2 beta
  • EIF 2 gamma
  • EIF 2alpha
  • EIF 2beta
  • EIF 2gamma
  • Eukaryotic Initiation Factor 2, alpha Subunit
  • Eukaryotic Initiation Factor 2, beta Subunit
  • Eukaryotic Initiation Factor 2, gamma Subunit

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003(1990)

MeSH Record

Previous Indexing

  • Peptide Initiation Factors (1978-1989)

MeSH Hierarchy

Tree Number

  1. D12.776w.835w.725w.868w.249w

AMA Style

References

  1. National Library of Medicine. Eukaryotic Initiation Factor-2. Medical Subject Headings (MeSH). 2026. Unique ID D015852. http://id.nlm.nih.gov/mesh/2026/D015852
  2. Eukaryotic Initiation Factor-2. In: Wikipedia. https://en.wikipedia.org/wiki/EIF2
  3. Eukaryotic Initiation Factor-2. In: Wikidata. https://www.wikidata.org/wiki/Q1017133