Chemicals and Drugs

Ethacrynic Acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Chemical Identity

Chemical Information

Molecular Formula
C13H12Cl2O4
Molecular Weight
303.13 g/mol
CAS Registry No.
58-54-8
IUPAC Name
2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
InChIKey
AVOLMBLBETYQHX-UHFFFAOYSA-N
SMILES
CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
MeSH Unique ID
D004976
Source
PubChem CID 3278

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Etacrynic Acid
  • Ethacrinic Acid
  • Acid, Etacrynic
  • Acid, Ethacrinic
  • Acid, Ethacrynic
  • Edecrin
  • Ethacrynate Sodium
  • Ethacrynic Acid, Sodium Salt
  • Hydromedin
  • Sodium, Ethacrynate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

66(63)

MeSH Hierarchy

Tree Numbers

  1. D02w.241w.081.018w.386.682.300w
  2. D02w.241w.511w.316.682.200w

AMA Style

References

  1. National Library of Medicine. Ethacrynic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D004976. http://id.nlm.nih.gov/mesh/2026/D004976
  2. Ethacrynic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Etacrynic_acid
  3. Ethacrynic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q418571
  4. Ethacrynic Acid. In: PubChem Compound. CID 3278. https://pubchem.ncbi.nlm.nih.gov/compound/3278