Chemicals and Drugs

Erythromycin Ethylsuccinate

A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Chemical Identity

Chemical Information

Molecular Formula
C43H75NO16
Molecular Weight
862.1 g/mol
CAS Registry No.
1264-62-6
IUPAC Name
4-O-[(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyloxan-3-yl] 1-O-ethyl butanedioate
InChIKey
NSYZCCDSJNWWJL-YXOIYICCSA-N
SMILES
CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)OC(=O)CCC(=O)OCC)(C)O)C)C)O)(C)O
MeSH Unique ID
D015643
Source
PubChem CID 443953

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Eyrthromycin Ethyl Succinate
  • Ethyl Succinate, Eyrthromycin
  • Ethylsuccinate, Erythromycin
  • Succinate, Eyrthromycin Ethyl
  • E-Mycin E
  • EryPed
  • Erythroped
  • Monomycin
  • Pediamycin
  • Wyamycin E
  • EMycin E

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Erythromycin (1966-1989)

MeSH Hierarchy

Tree Number

  1. D02w.540w.576w.500w.992w.260

AMA Style

References

  1. National Library of Medicine. Erythromycin Ethylsuccinate. Medical Subject Headings (MeSH). 2026. Unique ID D015643. http://id.nlm.nih.gov/mesh/2026/D015643
  2. Erythromycin Ethylsuccinate. In: Wikidata. https://www.wikidata.org/wiki/Q27114406
  3. Erythromycin Ethylsuccinate. In: PubChem Compound. CID 443953. https://pubchem.ncbi.nlm.nih.gov/compound/443953