Structured Summary
Abstract
A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.
Chemical Identity
Chemical Information
- Molecular Formula
- C24H30O6
- Molecular Weight
- 414.5 g/mol
- CAS Registry No.
- 107724-20-9
- IUPAC Name
- methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate
- InChIKey
- JUKPWJGBANNWMW-VWBFHTRKSA-N
- SMILES
- C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC
- MeSH Unique ID
- D000077545
- Source
- PubChem CID 443872
MeSH Record
Classification
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
3 entry terms
- Eplerenon
- 9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone
- Inspra
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (2000)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Eplerenone. Medical Subject Headings (MeSH). 2026. Unique ID D000077545. http://id.nlm.nih.gov/mesh/2026/D000077545
- Eplerenone. In: Wikipedia. https://en.wikipedia.org/wiki/Eplerenone
- Eplerenone. In: Wikidata. https://www.wikidata.org/wiki/Q423804
- Eplerenone. In: PubChem Compound. CID 443872. https://pubchem.ncbi.nlm.nih.gov/compound/443872